Postdoctoral Fellow - Pediatric Glioma Research
Fixed-term 3 years.
A Postdoctoral Fellow position is available in a dynamic team of the Gustave Roussy Cancer Campus Research Center in Paris area (Villejuif), France. The team headed by Dr Jacques Grill is presently one of the core labs of the CNRS unit UMR 8203 (Vectorology and New Anticancer Therapies) dedicated to the "Identification of targets and innovative therapies in pediatric tumors". Our research is currently focused on pediatric glial tumors. In the past few years, the lab contributed to the definition and biological understanding of several subtypes of pediatric gliomas and their distinction from their adult counterparts. These contributions enabled the definition of a new entity in the WHO classification, named "midline infiltrative glioma with H3K27M mutation".
However, driver oncogenic events are not identified in many other glial tumors, thus precluding the development of suitable therapeutics. There is therefore an interesting opportunity to discover new oncogenic processes involved in these rare and poorly studied tumors. The position is open to develop a new line of research in the field of these "atypical" infiltrative gliomas in children and adolescent, benefiting from the integrated and advanced research program of the lab on H3K27M mutant midline infiltrative glioma. A research consortium has been created in Paris grouping the Necker Sick Children's Hospital (Neurosurgery & Neuroradiology), the Neuropathology Reference Center of Sainte Anne Hospital, the Institut Pasteur and the CEA I2BM NeuroSpin (Advanced Brain Imaging Platform) to provide the necessary infrastructures for integrative biology and imaging of these types of neoplasms.
The research team is also associated with the Department of Pediatric and Adolescent Oncology of Gustave Roussy, which is the largest unit taking care of pediatric solid tumors in Europe with a special focus on brain tumors. This allowed to accumulate large cohorts of patients with banked biological material as well as to develop both in vitro and in vivo models.
Our strategies start from the exhaustive molecular characterization of primary tumors using state of the art genomic methods (WES, RNA-seq, ChIP-seq, shRNA and CRISPR screens) to understand the original biology of these neoplasms and to discover specific therapeutic targets than can be subsequently tested in our relevant cancer models.
The lab is also leading several precision medicine & rare tumour sequencing programs (BIOMEDE, RARE), reinforcing the translational aspect of the research conducted.
The team is composed of three senior scientists, 1 engineer dedicated to bioinformatics analysis, 1 assistant engineer dedicated to in vivo experimentation, 3 technicians and 4 PhD students.
Lab website for further information: https://www.gustaveroussy.fr/en/content/identification-new-targets-and-innovative-therapies-paediatric-cancers-current-research
- Carry out an independent research project and collaborate with other researchers and technicians in the lab and in the institution.
- Supervise junior members of the lab, including undergraduate & graduate students.
- Keep a log of lab materials as necessary (e.g. patient's samples, cell lines, mouse models, constructs).
- Present research in national/ international conferences.
Skills and qualifications:
- Candidates should have a PhD or a first post-doctoral experience in any relevant field of life sciences with a demonstrated record of excellent problem-solving skills.
- Strong expertise in Genomics and Epigenomics is mandatory.
- Additional experience in either of the following will be an asset: Cell biology, Molecular Biology, Brain Development or Glioma Biology.
- Strong written and oral communication
- Self-motivated and well-organized with good communication and technical skills.
- Able to work independently and collaborate effectively in a highly diverse and interdisciplinary team.
Interested applicants should submit
1) a cover letter, including a statement of previous and current research experiences,
2) a CV and the names/contact details of at least two references.
Please send requests and applications to: firstname.lastname@example.org
please quote ref. "www.123bio.eu/Postdoctoral Fellow"
Closing date for applications: 17th February 2017, however applications will be considered and reviewed on an on-going basis
and therefore the post maybe filled before the deadline.
About Gustave Roussy Cancer Campus
Gustave Roussy is the first European Cancer Centre and is among the ten world leaders in oncology research and care. Thirty-five research teams accounting for 300 researchers are involved in all aspect of oncology research: fundamental, clinical and translational. The integrative research is also supported by high-level core facilities (genomics, microscopy, cytometry and animal house).